Chemicals assist in converting raw materials into consumer customer-ready food packaging materials. Over 10,000 chemicals are approved for direct food contact worldwide. In packaging, we strive to be more sustainable. Furthermore, to ensure we can recycle, reuse and degrade packaging safely, best practices can be applied to remove chemicals of concern from packaging. Perchlorate is rapidly becoming the next chemical (after PFAS), gaining public attention. Since its use started, exposure levels to Perchlorate exceed that allowed in children. This exposure could have been avoided and this research explores how the packaging value chain can be applied to reduce the current use of chemicals of concern such as Perchlorate and ensure that further ones are not approved. A case study using Perchlorate in reusable totes for dry business-to-business (B2B) ingredients (cereal grain, flour) will be used to frame the situation as well as to define value chain factors proactively reduce the risk of something like Perchlorate from being used. Specific value chain strategies proactively reduce the risk of something like Perchlorate being used in the reusable totes for dry B2B ingredients (cereal grain, flour). Interviews with packaging professionals and value chain members are used to construct best practices using the value chain concepts of shared work, building trust, clusters, and managing knowledge. Best practices throughout the value chain in managing and eradicating chemicals of concern are defined. This includes building trust incentives, balancing costs, developing technology to establish a chain of custody and define fraudulent packaging, intelligent packaging, and research clusters. And these value chain best practices can be applied to perspective additives that may be chemicals of concern. The consequence of applying advanced value chain concepts is a more focused, pragmatic, and trustworthy food packaging industry. Speaker: Claire Sand, PhD